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1

mTOR mediated anti-cancer drug discovery

Qingsong Liu, Carson Thoreen, Jinhua Wang, David Sabatini, Nathanael S. Gray

Journal:

Drug Discovery Today: Therapeutic Strategies

Year:

2009

Language:

english

File:

PDF, 467 KB

english, 2009

2

The molecular basis of mTORC1-regulated translation

Thoreen, Carson C.

Journal:

Biochemical Society Transactions

Year:

2017

Language:

english

File:

PDF, 409 KB

english, 2017

3

Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability

Qingsong Liu, Jinhua Wang, Seong A. Kang, Carson C. Thoreen, Wooyoung Hur, Hwan Geun Choi, David L. Waller, Taebo Sim, David M. Sabatini, Nathanael S. Gray

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.54 MB

english, 2011

4

A proteomics approach to understanding protein ubiquitination

Peng, Junmin, Schwartz, Daniel, Elias, Joshua E, Thoreen, Carson C, Cheng, Dongmei, Marsischky, Gerald, Roelofs, Jeroen, Finley, Daniel, Gygi, Steven P

Journal:

Nature Biotechnology

Year:

2003

Language:

english

File:

PDF, 237 KB

english, 2003

5

Huntingtin aggregates ask to be eaten

Thoreen, Carson C, Sabatini, David M

Journal:

Nature Genetics

Year:

2004

Language:

english

File:

PDF, 90 KB

english, 2004

6

A unifying model for mTORC1-mediated regulation of mRNA translation

Thoreen, Carson C., Chantranupong, Lynne, Keys, Heather R., Wang, Tim, Gray, Nathanael S., Sabatini, David M.

Journal:

Year:

2012

Language:

english

File:

PDF, 936 KB

english, 2012

7

Evaluation of Multidimensional Chromatography Coupled with Tandem Mass Spectrometry (LC/LC−MS/MS) for Large-Scale Protein Analysis: The Yeast Proteome

Peng, Junmin, Elias, Joshua E., Thoreen, Carson C., Licklider, Larry J., Gygi, Steven P.

Journal:

Journal of Proteome Research

Year:

2003

Language:

english

File:

PDF, 203 KB

english, 2003

8

Functional Genomics Identifies TOR-Regulated Genes that Control Growth and Division

David A. Guertin, Kalyani V.P. Guntur, George W. Bell, Carson C. Thoreen, David M. Sabatini

Journal:

Current Biology

Year:

2006

Language:

english

File:

PDF, 907 KB

english, 2006

9

mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s

Maria A. Frias, Carson C. Thoreen, Jacob D. Jaffe, Wayne Schroder, Tom Sculley, Steven A. Carr, David M. Sabatini

Journal:

Current Biology

Year:

2006

Language:

english

File:

PDF, 399 KB

english, 2006

10

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

Timothy R. Peterson, Mathieu Laplante, Carson C. Thoreen, Yasemin Sancak, Seong A. Kang, W. Michael Kuehl, Nathanael S. Gray, David M. Sabatini

Journal:

Year:

2009

Language:

english

File:

PDF, 2.00 MB

english, 2009

11

AMPK and p53 help cells through lean times

Carson C. Thoreen, David M. Sabatini

Journal:

Cell Metabolism

Year:

2005

Language:

english

File:

PDF, 80 KB

english, 2005

12

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

David A. Guertin, Deanna M. Stevens, Carson C. Thoreen, Aurora A. Burds, Nada Y. Kalaany, Jason Moffat, Michael Brown, Kevin J. Fitzgerald, David M. Sabatini

Journal:

Developmental Cell

Year:

2006

Language:

english

File:

PDF, 1.92 MB

english, 2006

13

PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase

Yasemin Sancak, Carson C. Thoreen, Timothy R. Peterson, Robert A. Lindquist, Seong A. Kang, Eric Spooner, Steven A. Carr, David M. Sabatini

Journal:

Year:

2007

Language:

english

File:

PDF, 1.65 MB

english, 2007

14

Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[ h ][1,6]naphthyridin-2(1 H )-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of Cancer

Liu, Qingsong, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Ahmed, Tausif, Sabatini, David M., Gray, Nathanael S.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.42 MB

english, 2011

15

Automation of Nanoscale Microcapillary Liquid Chromatography−Tandem Mass Spectrometry with a Vented Column

Licklider, Lawrence J., Thoreen, Carson C., Peng, Junmin, Gygi, Steven P.

Journal:

Analytical Chemistry

Year:

2002

Language:

english

File:

PDF, 163 KB

english, 2002

16

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1 H )-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer

Liu, Qingsong, Chang, Jae Won, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Markhard, Andrew, Hur, Wooyoung, Zhang, Jianming, Sim, Taebo, Sabatini, David M., Gray, Nathanael S.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.22 MB

english, 2010

17

Many roads from mTOR to eIF4F

Thoreen, Carson C.

Journal:

Biochemical Society Transactions

Year:

2013

Language:

english

File:

PDF, 87 KB

english, 2013

18

Cooperative nutrient accumulation sustains growth of mammalian cells

Son, Sungmin, Stevens, Mark M., Chao, Hui Xiao, Thoreen, Carson, Hosios, Aaron M., Schweitzer, Lawrence D., Weng, Yaochung, Wood, Kris, Sabatini, David, Vander Heiden, Matthew G., Manalis, Scott

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.02 MB

english, 2015

19

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

Park, Yeonwoo, Reyna-Neyra, Andrea, Philippe, Lucas, Thoreen, Carson C.

Journal:

Year:

2017

Language:

english

File:

PDF, 2.11 MB

english, 2017

20

La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region

Philippe, Lucas, Vasseur, Jean-Jacques, Debart, Françoise, Thoreen, Carson C.

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 1.12 MB

english, 2017

21

Loss of protein synthesis quality control in host-restricted organisms

Melnikov, Sergey V., van den Elzen, Antonia, Stevens, David L., Thoreen, Carson C., Söll, Dieter

Journal:

Proceedings of the National Academy of Sciences

Year:

2018

Language:

english

File:

PDF, 4.04 MB

english, 2018

22

Archaeal ribosomal proteins possess nuclear localization signal-type motifs: implications for the origin of the cell nucleus

Melnikov, Sergey, Kwok, Hui-Si, Manakongtreecheep, Kasidet, van den Elzen, Antonia, Thoreen, Carson C, Söll, Dieter, Wilke, Claus

Journal:

Molecular Biology and Evolution

Year:

2019

Language:

english

File:

PDF, 2.06 MB

english, 2019

23

Archaeal ribosomal proteins possess nuclear localization signal-type motifs: implications for the origin of the cell nucleus

Melnikov, Sergey, Kwok, Hui-Si, Manakongtreecheep, Kasidet, van den Elzen, Antonia, Thoreen, Carson C, Söll, Dieter, Wilke, Claus

Journal:

Molecular Biology and Evolution

Year:

2019

File:

PDF, 2.06 MB

2019

24

Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5â² TOP motifs

Philippe, Lucas, van den Elzen, Antonia M. G., Watson, Maegan J., Thoreen, Carson C.

Journal:

Proceedings of the National Academy of Sciences

Year:

2020

File:

PDF, 1.40 MB

2020

25

Correction: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

Thoreen, Carson C., Kang, Seong A., Chang, Jae Won, Liu, Qingsong, Zhang, Jianming, Gao, Yi, Reichling, Laurie J., Sim, Taebo, Sabatini, David M., Gray, Nathanael S.

Journal:

Journal of Biological Chemistry

Year:

2020

File:

PDF, 240 KB

2020

26

La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region

Philippe, Lucas, Vasseur, Jean-Jacques, Debart, FranÃ§oise, Thoreen, Carson C

Journal:

Nucleic Acids Research

Year:

2020

File:

PDF, 849 KB

2020

27

Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells

Son, Sungmin, Stevens, Mark M., Chao, Hui Xiao, Thoreen, Carson, Hosios, Aaron M., Schweitzer, Lawrence D., Weng, Yaochung, Wood, Kris, Sabatini, David, Vander Heiden, Matthew G., Manalis, Scott

Journal:

Scientific Reports

Year:

2020

File:

PDF, 927 KB

2020

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